HORDB

ID: hor005849
Uniprot ID: Q23212
Protein name: NPLGTMRF-amide
Gene name: flp-3
Organism: Caenorhabditis elegans
Family: FARP (FMRFamide related peptide) family
Source: animal
Expression: Expressed from the comma stage of embryogenesis, during all larval stages, and in adults. |Each flp gene is expressed in a distinct set of neurons. Flp-3 is expressed in the IL1 and PQR neurons.
Disease: NA
Comments: NA
Taxonomy: Caenorhabditis (genus), Peloderinae (subfamily), Rhabditidae (family), Rhabditoidea (superfamily), Rhabditomorpha (infraorder), Rhabditina (suborder), Rhabditida (order), Chromadorea (class), Nematoda (phylum), Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0007218 neuropeptide signaling pathway; GO:0043051 regulation of nematode pharyngeal pumping; GO:0045759 negative regulation of action potential
GO CC: GO:0005576 extracellular region

Sequence: NPLGTMRF
Length: 8
Propeptide: MISPNHLILLFCVNCAFLVASDATPKRSPLGTMRFGKRAIADEMTFEEDGYYPSNVMWKRSTVDSSEPVIRDQRTPLGTMRFGKRSAEPFGTMRFGKRNPENDTPFGTMRFGKRASEDALFGTMRFGKREDGNAPFGTMKFGKREAEEPLGTMRFGKRSADDSAPFGTMRFGKRNPLGTMRFGK
Signal peptide: MISPNHLILLFCVNCAFLVASDA
Modification: T8 Phenylalanine amide
Glycosylation: NA
Mutagenesis: NA

Function: FMRFamides and FMRFamide-like peptides are neuropeptides. SAEPFGTMRF-amide inhibits the activity of dissected pharyngeal myogenic muscle system.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor005849_AF2.pdb

hor005849_ESM.pdb

Mass:	106014	Formula:	C41H66N12O11S
Absent amino acids:	ACDEHIKQSVWY	Common amino acids:	FGLMNPRT
pI:	10.55	Basic residues:	1
Polar residues:	3	Hydrophobic residues:	2
Hydrophobicity:	-27.5	Boman Index:	-1294
Half-Life:	1.4 hour	Half-Life Yeast:	3 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	48.75
Instability Index:	-1488.75	Extinction Coefficient cystines:	0
Absorbance 280nm:	0

PubMed ID: 9685599
Title: FMRFamide-related gene family in the nematode, Caenorhabditis elegans.
PubMed ID: 9851916
Title: Genome sequence of the nematode C. elegans: a platform for investigating biology.
PubMed ID: 16061202
Title: Discovering neuropeptides in Caenorhabditis elegans by two dimensional liquid chromatography and mass spectrometry.
PubMed ID: 15236235
Title: Expression and regulation of an FMRFamide-related neuropeptide gene family in Caenorhabditis elegans.
PubMed ID: 16187307
Title: Role of a FMRFamide-like family of neuropeptides in the pharyngeal nervous system of Caenorhabditis elegans.